KMID : 1130320100530010033
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Korean Journal of Pediatrics 2010 Volume.53 No. 1 p.33 ~ p.40
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Influence of histologic chorioamnionitis and funisitis on the level of peripheral blood C-reactive protein at birth in preterm infants
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Kim Do-Hyeon
Lee Heun-Ji Kim Hee-Sup Yoo Byung-Hoon
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Abstract
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Purpose: The objective of this study is to determine the change of C-reactive protein (CRP) levels in the peripheral blood of preterm infants at birth according to the stage of intrauterine inflammation.
Methods: A total of 187 infants (<32 weeks of gestation) were divided into a ¡°no histologic chorioamnionitis¡± [HCAM (-), n=85] group and a ¡°histologic chorioamnionitis¡± [HCAM (+), n=102] group according to placental pathologic findings. Furthermore, the HCAM (+) group was subdivided into a ¡°funisitis¡± [F (+), n=49] group and a ¡°no funisitis¡± [F (-), n=53] group and also into a ¡°funisitis/amnionitis¡± [FA (+), n=58] group and an ¡°isolated chorio-deciduitis¡± [FA (-), n=44] group. High-sensitivity CRP levels in the peripheral blood at birth were measured.
Results: Peripheral blood CRP levels were significantly higher in the HCAM (+), F (+), F (-), and FA (+) groups than in the HCAM (-) group, but were not significantly different between the FA (-) and HCAM (-) groups. In addition, peripheral blood CRP levels were significantly higher in the F (+) and FA (+) groups than in the F (-) and FA (-) groups, respectively. For identification of amnionitis or funisitis, a cut-off value of 0.02 mg/dL was chosen. Clinical chorioamnionitis, proven early onset sepsis, histologic chorioamnionitis, and funisitis had higher incidences in infants with peripheral blood CRP levels higher than 0.02 mg/dL.
Conclusion: The present study shows that peripheral blood CRP levels at birth in preterm infants born before 32 weeks¡¯ gestation is significantly increased in amnionitis or funisitis and might reflect the progress of histologic chorioamnionitis.
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KEYWORD
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C-reactive protein, Peripheral blood, Chorioamnionitis, Funisitis, Amnionitis
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